Tag SNP selection via a genetic algorithm
نویسندگان
چکیده
منابع مشابه
Tag SNP selection via a genetic algorithm
Single Nucleotide Polymorphisms (SNPs) provide valuable information on human evolutionary history and may lead us to identify genetic variants responsible for human complex diseases. Unfortunately, molecular haplotyping methods are costly, laborious, and time consuming; therefore, algorithms for constructing full haplotype patterns from small available data through computational methods, Tag SN...
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Single nucleotide polymorphisms (SNPs) hold much promise as a basis for disease-gene association. However, research is limited by the cost of genotyping the tremendous number of SNPs. Therefore, it is important to identify a small subset of informative SNPs, the so-called tag SNPs. This subset consists of selected SNPs of the genotypes, and accurately represents the rest of the SNPs. Furthermor...
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Discovering statistical correlation between causal genetic variation and clinical traits through association studies is an important method for identifying the genetic basis of human diseases. Since fully resequencing a cohort is prohibitively costly, genetic association studies take advantage of local correlation structure (or linkage disequilibrium) between single nucleotide polymorphisms (SN...
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OBJECTIVE Genomic studies provide large volumes of data with the number of single nucleotide polymorphisms (SNPs) ranging into thousands. The analysis of SNPs permits determining relationships between genotypic and phenotypic information as well as the identification of SNPs related to a disease. The growing wealth of information and advances in biology call for the development of approaches fo...
متن کاملTag SNP Selection Based on Multivariate Linear Regression
The search for the association between complex diseases and single nucleotide polymorphisms (SNPs) or haplotypes has been recently received great attention. For these studies, it is essential to use a small subset of informative SNPs (tag SNPs) accurately representing the rest of the SNPs. Tagging can achieve budget savings by genotyping only a limited number of SNPs and computationally inferri...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2010
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2010.05.011